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Valpros: Known hypersensitivity to sodium valproate, valproic acid or to any ingredient in the product; Patients with pre-existing, acute or chronic hepatic dysfunction or family history of severe hepatic dysfunction, particularly drug related; Patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase-γ gene (POLG; e.g., Alpers-Huttenlocher Syndrome) and children under two years old who are suspected of having a POLG-related disorder; Patients with known urea cycle disorders; Patients with porphyria.
Valpros i-IV: Hypersensitivity to sodium valproate or any ingredient of the product; Urea cycle disorder; Porphyria; Pre-existing or acute hepatic dysfunction; Personal or family history of severe hepatitis, particularly medicine related.
